The Mechanism of Selective Protein Degradation: An Analysis of Proteolysis Targeting Chimeras
The most exciting aspect of PROTAC technology is its ability to target proteins that were previously considered "undruggable." Traditional drugs work by binding to a specific "active site" on a protein, but many harmful proteins don't have these sites. PROTACs only need to bind anywhere on the surface to trigger destruction, opening up a vast range of new targets for treating cancer and Alzheimer's.
